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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
Inotropic therapy does not have a role in the treatment of most heart failure patients. These drugs can make patients feel and function better but usually do not lengthen the predicted length of their lives.
The immune system needs 9.5 hours of sleep in total darkness to recharge completely.
On average, the stomach produces 2 L of hydrochloric acid per day.
This year, an estimated 1.4 million Americans will have a new or recurrent heart attack.