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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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The heart is located in the center of the chest, with part of it tipped slightly so that it taps against the left side of the chest.
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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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Although puberty usually occurs in the early teenage years, the world's youngest parents were two Chinese children who had their first baby when they were 8 and 9 years of age.
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In 1864, the first barbiturate (barbituric acid) was synthesized.