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Throughout history, plants containing cardiac steroids have been used as heart drugs and as poisons (e.g., in arrows used in combat), emetics, and diuretics.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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The toxic levels for lithium carbonate are close to the therapeutic levels. Signs of toxicity include fine hand tremor, polyuria, mild thirst, nausea, general discomfort, diarrhea, vomiting, drowsiness, muscular weakness, lack of coordination, ataxia, giddiness, tinnitus, and blurred vision.
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Aspirin is the most widely used drug in the world. It has even been recognized as such by the Guinness Book of World Records.
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The ratio of hydrogen atoms to oxygen in water (H2O) is 2:1.