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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.

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In 1885, the Lloyd Manufacturing Company of Albany, New York, promoted and sold "Cocaine Toothache Drops" at 15 cents per bottle! In 1914, the Harrison Narcotic Act brought the sale and distribution of this drug under federal control.

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Human neurons are so small that they require a microscope in order to be seen. However, some neurons can be up to 3 feet long, such as those that extend from the spinal cord to the toes.

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The first war in which wide-scale use of anesthetics occurred was the Civil War, and 80% of all wounds were in the extremities.

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Bacteria have flourished on the earth for over three billion years. They were the first life forms on the planet.

Schematic representation of MHC class I molecule, consisting of 3 α domains and 1 β2-microglobulin ... Schematic representation of MHC class I molecule, consisting of 3 α domains and 1 β2-microglobulin ...
Neck and Occipital Ridge. Apply thumb compression across the area at the base of the big toe. One ... Neck and Occipital Ridge. Apply thumb compression across the area at the base of the big toe. One ...
Another class of dihydrofolate reductase inhibitors is exemplified by trimethoprim Another class of dihydrofolate reductase inhibitors is exemplified by trimethoprim
Cold Front Cold Front
Frontal section showing location of auditory ossicles in the middle ear Frontal section showing location of auditory ossicles in the middle ear
Frontal section of primary somatosensory area in right cerebral hemisphere Frontal section of primary somatosensory area in right cerebral hemisphere
Video: Kinetic parameters & Kinetic experiment

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