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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.

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Illicit drug use costs the United States approximately $181 billion every year.

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The FDA recognizes 118 routes of administration.

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It is difficult to obtain enough calcium without consuming milk or other dairy foods.

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Serum cholesterol testing in adults is recommended every 1 to 5 years. People with diabetes and a family history of high cholesterol should be tested even more frequently.

In pretend play, toy figures and animals “come to life” and interact with each other. In pretend play, toy figures and animals “come to life” and interact with each other.
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