This topic contains a solution. Click here to go to the answer
« previous next »

Author Question: Describe the role of the locus coeruleus in the development of opiate withdrawal symptoms. What ... (Read 33 times)

nevelica

  • Hero Member
  • *****
  • Posts: 563
on: Jun 22, 2018
Describe the role of the locus coeruleus in the development of opiate withdrawal symptoms.
 
  What will be an ideal response?

Question 2

Describe the types of approaches that are being taken today to treat drug abuse.
 
  What will be an ideal response?


Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
Marked as best answer by a Subject Expert

brittanywood

  • Sr. Member
  • ****
  • Posts: 355
Reply #1 on: Jun 22, 2018
Answer to Question 1

Answer: Withdrawal from opiates results in hyperthermia, pain, nausea, and malaise. Opiate withdrawal can be induced by stopping opiate treatment with the symptoms coming on gradually. Animal studies often use injection of naloxone (an opiate receptor antagonist) to rapidly induce withdrawal. Injection of naloxone into the locus coeruleus (LC) rapidly triggers withdrawal symptoms. Opiates suppress the firing rate of LC neurons but naloxone greatly increases their firing rate. Damage to the LC reduces symptoms of opiate withdrawal.

Answer to Question 2

Answer: One approach is to administer a drug that blocks dopamine receptors, so as to prevent the reinforcing action of the drug of abuse. This, however, can lead to drug craving. Administering a long-acting drug that substitutes for the drug of abuse (e.g., methadone) may help during the drug withdrawal process. A recently developed technique is to develop an antibody to the drug of abuse.


nevelica

  • Member
  • Posts: 563
Reply 2 on: Jun 22, 2018
:D TYSM

milbourne11

  • Member
  • Posts: 322
Reply 3 on: Yesterday
Great answer, keep it coming :)

« previous next »
 

Did you know?

Oliver Wendell Holmes is credited with introducing the words "anesthesia" and "anesthetic" into the English language in 1846.

Did you know?

Patients who cannot swallow may receive nutrition via a parenteral route—usually, a catheter is inserted through the chest into a large vein going into the heart.

Did you know?

A recent study has found that following a diet rich in berries may slow down the aging process of the brain. This diet apparently helps to keep dopamine levels much higher than are seen in normal individuals who do not eat berries as a regular part of their diet as they enter their later years.

Did you know?

People who have myopia, or nearsightedness, are not able to see objects at a distance but only up close. It occurs when the cornea is either curved too steeply, the eye is too long, or both. This condition is progressive and worsens with time. More than 100 million people in the United States are nearsighted, but only 20% of those are born with the condition. Diet, eye exercise, drug therapy, and corrective lenses can all help manage nearsightedness.

Did you know?

Blood is approximately twice as thick as water because of the cells and other components found in it.

Signs and symptoms of breathing difficulty. Signs and symptoms of breathing difficulty.
Kohlberg's Stages of Moral Development Kohlberg's Stages of Moral Development
The development of an ovary and a testis from the cortex and the medulla, respectively, of the ... The development of an ovary and a testis from the cortex and the medulla, respectively, of the ...
Human Development and Remittances Human Development and Remittances
Six-week embryo showing development of hand and foot plates Six-week embryo showing development of hand and foot plates
Some of the Alleles present at white locus Some of the Alleles present at white locus
Video: Double Vacuum Process (Illustration No Audio)

For a complete list of videos, visit our video library