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In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
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By definition, when a medication is administered intravenously, its bioavailability is 100%.
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Oliver Wendell Holmes is credited with introducing the words "anesthesia" and "anesthetic" into the English language in 1846.
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It is believed that the Incas used anesthesia. Evidence supports the theory that shamans chewed cocoa leaves and drilled holes into the heads of patients (letting evil spirits escape), spitting into the wounds they made. The mixture of cocaine, saliva, and resin numbed the site enough to allow hours of drilling.
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The average office desk has 400 times more bacteria on it than a toilet.