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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.

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The Food and Drug Administration has approved Risperdal, an adult antipsychotic drug, for the symptomatic treatment of irritability in children and adolescents with autism. The approval is the first for the use of a drug to treat behaviors associated with autism in children. These behaviors are included under the general heading of irritability and include aggression, deliberate self-injury, and temper tantrums.

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Pope Sylvester II tried to introduce Arabic numbers into Europe between the years 999 and 1003, but their use did not catch on for a few more centuries, and Roman numerals continued to be the primary number system.

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Everyone has one nostril that is larger than the other.

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In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.

In vitro oligonucleotide site-directed mutagenesis In vitro oligonucleotide site-directed mutagenesis
In the heat of the Battle of Lake Erie, Perry had to abandon his flagship, the Lawrence, which had b In the heat of the Battle of Lake Erie, Perry had to abandon his flagship, the Lawrence, which had b
snoRNP-directed modification of pre-rRNA snoRNP-directed modification of pre-rRNA
Algorithm for assessing a patient at risk for self-directed violence. Algorithm for assessing a patient at risk for self-directed violence.
The air flowing into the engine can be directed through long or short runners for best performance ... The air flowing into the engine can be directed through long or short runners for best performance ...
Peptide Arrays - light-directed, spatially patterned oligopeptide synthesis Peptide Arrays - light-directed, spatially patterned oligopeptide synthesis
Video: Autonomic Nervous System Animation

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