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Once thought to have neurofibromatosis, Joseph Merrick (also known as "the elephant man") is now, in retrospect, thought by clinical experts to have had Proteus syndrome. This endocrine disease causes continued and abnormal growth of the bones, muscles, skin, and so on and can become completely debilitating with severe deformities occurring anywhere on the body.
Intradermal injections are somewhat difficult to correctly administer because the skin layers are so thin that it is easy to accidentally punch through to the deeper subcutaneous layer.
The first war in which wide-scale use of anesthetics occurred was the Civil War, and 80% of all wounds were in the extremities.
More than 20 million Americans cite use of marijuana within the past 30 days, according to the National Survey on Drug Use and Health (NSDUH). More than 8 million admit to using it almost every day.
More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
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![In 1839 Mary Cragin, at the age of twenty-nine, became a convert to John Humphrey Noyes’s “communism](https://biology-forums.com/gallery/47/medium_375348_18_08_15_9_36_29_222991202.jpeg)