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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.

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When blood is exposed to air, it clots. Heparin allows the blood to come in direct contact with air without clotting.

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More than 150,000 Americans killed by cardiovascular disease are younger than the age of 65 years.

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The longest a person has survived after a heart transplant is 24 years.

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In inpatient settings, adverse drug events account for an estimated one in three of all hospital adverse events. They affect approximately 2 million hospital stays every year, and prolong hospital stays by between one and five days.

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