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Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
As the western states of America were settled, pioneers often had to drink rancid water from ponds and other sources. This often resulted in chronic diarrhea, causing many cases of dehydration and death that could have been avoided if clean water had been available.
Most fungi that pathogenically affect humans live in soil. If a person is not healthy, has an open wound, or is immunocompromised, a fungal infection can be very aggressive.
In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
Aspirin is the most widely used drug in the world. It has even been recognized as such by the Guinness Book of World Records.