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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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Illicit drug use costs the United States approximately $181 billion every year.
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On average, the stomach produces 2 L of hydrochloric acid per day.
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Between 1999 and 2012, American adults with high total cholesterol decreased from 18.3% to 12.9%
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Addicts to opiates often avoid treatment because they are afraid of withdrawal. Though unpleasant, with proper management, withdrawal is rarely fatal and passes relatively quickly.