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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
Symptoms of kidney problems include a loss of appetite, back pain (which may be sudden and intense), chills, abdominal pain, fluid retention, nausea, the urge to urinate, vomiting, and fever.
More than 150,000 Americans killed by cardiovascular disease are younger than the age of 65 years.
Asthma cases in Americans are about 75% higher today than they were in 1980.
Human stomach acid is strong enough to dissolve small pieces of metal such as razor blades or staples.