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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
The Romans did not use numerals to indicate fractions but instead used words to indicate parts of a whole.
There are approximately 3 million unintended pregnancies in the United States each year.
The shortest mature adult human of whom there is independent evidence was Gul Mohammed in India. In 1990, he was measured in New Delhi and stood 22.5 inches tall.