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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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Women are 50% to 75% more likely than men to experience an adverse drug reaction.
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Bacteria have been found alive in a lake buried one half mile under ice in Antarctica.
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Asthma cases in Americans are about 75% higher today than they were in 1980.
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During the twentieth century, a variant of the metric system was used in Russia and France in which the base unit of mass was the tonne. Instead of kilograms, this system used millitonnes (mt).