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There are 60,000 miles of blood vessels in every adult human.
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By definition, when a medication is administered intravenously, its bioavailability is 100%.
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Amphetamine poisoning can cause intravascular coagulation, circulatory collapse, rhabdomyolysis, ischemic colitis, acute psychosis, hyperthermia, respiratory distress syndrome, and pericarditis.
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Drug-induced pharmacodynamic effects manifested in older adults include drug-induced renal toxicity, which can be a major factor when these adults are experiencing other kidney problems.
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In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.