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Acetaminophen (Tylenol) in overdose can seriously damage the liver. It should never be taken by people who use alcohol heavily; it can result in severe liver damage and even a condition requiring a liver transplant.
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Intradermal injections are somewhat difficult to correctly administer because the skin layers are so thin that it is easy to accidentally punch through to the deeper subcutaneous layer.
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By definition, when a medication is administered intravenously, its bioavailability is 100%.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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About 100 new prescription or over-the-counter drugs come into the U.S. market every year.