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In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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In 1844, Charles Goodyear obtained the first patent for a rubber condom.
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Human kidneys will clean about 1 million gallons of blood in an average lifetime.
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Patients should never assume they are being given the appropriate drugs. They should make sure they know which drugs are being prescribed, and always double-check that the drugs received match the prescription.