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Ether was used widely for surgeries but became less popular because of its flammability and its tendency to cause vomiting. In England, it was quickly replaced by chloroform, but this agent caused many deaths and lost popularity.
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Intradermal injections are somewhat difficult to correctly administer because the skin layers are so thin that it is easy to accidentally punch through to the deeper subcutaneous layer.
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About 100 new prescription or over-the-counter drugs come into the U.S. market every year.
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Earwax has antimicrobial properties that reduce the viability of bacteria and fungus in the human ear.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.