Which of the following statements is FALSE regarding gene therapy?
◦ Both somatic and germinal gene therapy have been successful in animal systems; but for ethical reasons, only somatic gene therapy has been attempted in humans.
◦ The integration of a transgene into the genome of the target cell by a viral vector is not permanent, and therefore it will require repeated treatments.
◦ The insertion of a vector may cause a detrimental mutation.
◦ Approaches with iPS cells avoid problems of immune system incompatibility, but are limited to diseases, like blood disorders, in which cells can be isolated, corrected, and reintroduced.
◦ iPS cells that continue to express the Yamanaka factors are predisposed to become cancerous.