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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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Signs of depression include feeling sad most of the time for 2 weeks or longer; loss of interest in things normally enjoyed; lack of energy; sleep and appetite disturbances; weight changes; feelings of hopelessness, helplessness, or worthlessness; an inability to make decisions; and thoughts of death and suicide.
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In 1844, Charles Goodyear obtained the first patent for a rubber condom.
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The first oncogene was discovered in 1970 and was termed SRC (pronounced "SARK").
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The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.