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More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
On average, someone in the United States has a stroke about every 40 seconds. This is about 795,000 people per year.
The use of salicylates dates back 2,500 years to Hippocrates's recommendation of willow bark (from which a salicylate is derived) as an aid to the pains of childbirth. However, overdosage of salicylates can harm body fluids, electrolytes, the CNS, the GI tract, the ears, the lungs, the blood, the liver, and the kidneys and cause coma or death.
For pediatric patients, intravenous fluids are the most commonly cited products involved in medication errors that are reported to the USP.
The first war in which wide-scale use of anesthetics occurred was the Civil War, and 80% of all wounds were in the extremities.

