All antiretroviral medications interfere with some stage of the ...

[Lisaclaire]

All antiretroviral medications interfere with some stage of the HIV life cycle. What stage do protease inhibitors prevent?
 
  A)
  Cleavage of the polyprotein chain into the individual proteins that will be used to make new virus
  B)
  Addition of more nucleosides to the DNA chain
  C)
  Killing of the CD4+ T cell to release virions into the bloodstream
  D)
  Attachment of the virus to CD4+ cell receptors

Question 2

While undergoing a kidney transplant from a nonfamily member, the patient's transplanted kidney has just had the arterial clamps removed. The OR staff notice that the organ is turning purple with no urine output.
 
  When explaining to the family why they had to remove the donor kidney, the nurse will anticipate that the surgeon would likely include which statement?
  A)
  Obviously, there has been a mismatch during the human leukocyte antigen (HLA) testing.
  B)
  The circulating B and T lymphocytes are just doing their job.
  C)
  Hyperacute rejection occurs because antibodies against HLA antigens are deposited in vessels causing necrosis.
  D)
  Previous exposure to the HLA antigens is responsible for the high titers of complement fixing antibodies that cause the rejection.

[zogaridan]

Answer to Question 1

Ans:
A

Feedback:

By binding to the protease enzyme and inhibiting its function, protease inhibitors prevent cleavage of the polyprotein chain into individual proteins. Virions are still released into the body, but they are immature and noninfectious.

Answer to Question 2

Ans:
C

Feedback:

Antibody-mediated rejection can be hyperacute, which occurs almost immediately after vascular reperfusion to graft tissue occurs. Performed antibodies against HLA antigens are deposited in the tissue endothelium and microvasculature where they activate the classic complement pathway causing tissue necrosis and graft injury.

[Lisaclaire]

Correct answers!

[zogaridan]

Great! Please up vote