What lymphoproliferative disorder has a very favorable response ...

[luminitza]

What lymphoproliferative disorder has a very favorable response to highly aggressive chemotherapy with no radiotherapy?
 
  a. Chronic lymphocytic leukemia
  b. Mycosis fungoides
  c. Hodgkin lymphoma
  d. Burkitt lymphoma

Question 2

Serum protein electrophoresis on an elderly patient reveals a monoclonal protein spike. Increased plasma cells are present in the bone marrow.
 
  They are CD19 and CD20 negative but demonstrate high-density CD38 and monoclonal cytoplasmic immunoglobulin. What is the most likely diagnosis?
 
  a. Plasma cell myeloma
  b. Hodgkin lymphoma
  c. Burkitt lymphoma
  d. Chronic lymphocytic leukemia

[bigcheese9]

Answer to Question 1

ANS: D
Burkitt lymphoma has a very favorable response rate to aggressive chemotherapy, primarily because most of the cells are in an active phase of the cell cycle at any one time. Cure rates are very high.

Answer to Question 2

ANS: A
Increased bone marrow plasma cells that are CD19 and CD20 negative but have high density CD38 and monoclonal cytoplasmic immunoglobulin are characteristic of plasma cell myeloma. A monoclonal protein spike is present when serum electrophoresis is performed.