This topic contains a solution. Click here to go to the answer

Author Question: Which of the following is true for the mutated erythroid progenitors in polycythemia vera? a. ... (Read 85 times)

Mimi

  • Hero Member
  • *****
  • Posts: 542
Which of the following is true for the mutated erythroid progenitors in polycythemia vera?
 
  a. They require extremely high levels of erythropoietin for growth in vitro.
  b. They are more resistant to apoptosis than normal erythroid progenitors.
  c. They mature abnormally, giving rise to a marked increase in poikilocytosis in peripheral blood.
  d. They are Philadelphia chromosome positive.

Question 2

The Janus kinase (JAK) mutation is seen in more than 90 of cases of what disease?
 
  a. Chronic myelogenous leukemia
  b. Primary myelofibrosis
  c. Plasma cell myeloma
  d. Polycythemia vera



Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
Marked as best answer by a Subject Expert

Athena23

  • Sr. Member
  • ****
  • Posts: 305
Answer to Question 1

ANS: B
The mutated erythroid progenitors in polycythemia vera are more resistant to apoptosis than normal erythroid progenitors. Thus they do not divide more rapidly (as once believed) but accumulate abnormally because they do not die normally. This results in an increased red cell mass in peripheral blood. Maturation is normal, giving rise to essentially morphologically normal red cells. They grow in vitro with trace concentrations of erythropoietin and are Philadelphia chromosome negative.

Answer to Question 2

ANS: D
The diagnosis of polycythemia vera requires the presence of two major criteria and one minor criteria, or it requires the first major criteria and two minor criteria. The JAK mutation is the second of the major criteria.





 

Did you know?

According to animal studies, the typical American diet is damaging to the liver and may result in allergies, low energy, digestive problems, and a lack of ability to detoxify harmful substances.

Did you know?

As many as 28% of hospitalized patients requiring mechanical ventilators to help them breathe (for more than 48 hours) will develop ventilator-associated pneumonia. Current therapy involves intravenous antibiotics, but new antibiotics that can be inhaled (and more directly treat the infection) are being developed.

Did you know?

In 1864, the first barbiturate (barbituric acid) was synthesized.

Did you know?

Recent studies have shown that the number of medication errors increases in relation to the number of orders that are verified per pharmacist, per work shift.

Did you know?

More than 30% of American adults, and about 12% of children utilize health care approaches that were developed outside of conventional medicine.

For a complete list of videos, visit our video library