Answer to Question 1
ANS: C
Hypersegmented neutrophils are consistently found early in megaloblastic anemia. Because they are not found in any other condition, they are considered specific. Thus they usually accompany macrocytic red cells (including macroovalocytes). Laboratories may use differing criteria for hypersegmentation. However, all would agree that observation of one six-lobed neutrophil is evidence of hypersegmentation. Some will do a neutrophil lobe count, and report hypersegmentation when the average is greater than 3.4.
Answer to Question 2
ANS: D
Both PA and folate deficiency have an elevated MCV, the presence of hypersegmented neutrophils, and megaloblastic bone marrow findings. However, only PA has autoantibodies to IF present.
A comparison between chromosomes found in a normal human cell and a cancer cell from the same person
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