What is the last granulocyte in the maturation sequence able to ...

[nmorano1]

What is the last granulocyte in the maturation sequence able to undergo mitosis?
 
  a. Myeloblast
  b. Promyelocyte
  c. Myelocyte
  d. Band

Question 2

What directs the mitosis and maturation action of progenitor neutrophil cells in the bone marrow?
 
  a. Erythropoietin
  b. The number of stem cells
  c. The number of mature cells in the peripheral circulation
  d. Colony-stimulating cytokines

[vboyd24]

Answer to Question 1

ANS: C
The myelocyte is the last granulocyte in the normal maturation sequence that can undergo mitosis. The myeloblast and promyelocyte precede the myelocyte; both can and do undergo mitosis. The band cell is no longer able to replicate its deoxyribonucleic acid (DNA) and so does not undergo mitosis.

Answer to Question 2

ANS: D
Colony-stimulating cytokines bind to receptors on progenitor cells to direct them to undergo mitosis and to mature to identifiable neutrophil precursor cells. Erythropoietin is the primary cytokine for red cell development. Neither the number of stem cells nor the number of mature cells in circulation function in this role.