This topic contains a solution. Click here to go to the answer

Author Question: Which is the most common FVIII mutation in patients with a severe phenotype (occurring in almost 50 ... (Read 62 times)

Alainaaa8

  • Hero Member
  • *****
  • Posts: 576
Which is the most common FVIII mutation in patients with a severe phenotype (occurring in almost 50 of patients)?
 
  a. Gross deletion of entire gene locus
  b. Point mutation involving the thrombin cleavage site
  c. Inversion mutation of intron 22
  d. Point mutation involving the site of VWF attachment

Question 2

Explain how liver disease can be differentiated from DIC through laboratory test analysis.
 
  What will be an ideal response?



Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
Marked as best answer by a Subject Expert

Natalie4ever

  • Sr. Member
  • ****
  • Posts: 335
Answer to Question 1

Correct Answer: C

Answer to Question 2

Answer: Liver disease has a significant impact on coagulation because several coagulation factors are synthesized in the liver. The result is a decreased level of coagulation proteins synthesized in the liver, whereas in DIC, all proteins decrease. Liver dysfunction also leads to procoagulant dysfunction and platelet sequestration. Protein dysfunction, especially fibrinogen, is associated with normal levels of proteins but is aberrantly dysfunctional. In addition, fibrinogen is an acute phase reactant and increases in inflammatory conditions. This can provide a differential diagnosis between liver disease and DIC because fibrinogen in DIC is consumed, but in liver disease, it often increases. Liver enzymes, in general, identify liver dysfunction as a whole, thus inferring that liver disease causes issues with coagulation proteins. DIC has excessive fibrinolysis in response to the excessive fibrin formed, which can cause the production of measurable D-dimers in a patient sample. In liver disease, fibrinolysis is normal.




Alainaaa8

  • Member
  • Posts: 576
Reply 2 on: Jun 25, 2018
Great answer, keep it coming :)


tranoy

  • Member
  • Posts: 344
Reply 3 on: Yesterday
YES! Correct, THANKS for helping me on my review

 

Did you know?

Despite claims by manufacturers, the supplement known as Ginkgo biloba was shown in a study of more than 3,000 participants to be ineffective in reducing development of dementia and Alzheimer’s disease in older people.

Did you know?

Approximately one in four people diagnosed with diabetes will develop foot problems. Of these, about one-third will require lower extremity amputation.

Did you know?

It is widely believed that giving a daily oral dose of aspirin to heart attack patients improves their chances of survival because the aspirin blocks the formation of new blood clots.

Did you know?

All patients with hyperparathyroidism will develop osteoporosis. The parathyroid glands maintain blood calcium within the normal range. All patients with this disease will continue to lose calcium from their bones every day, and there is no way to prevent the development of osteoporosis as a result.

Did you know?

It is important to read food labels and choose foods with low cholesterol and saturated trans fat. You should limit saturated fat to no higher than 6% of daily calories.

For a complete list of videos, visit our video library