« previous next »

Author Question: Interpret the following results: PT: 11.8 sec (RR: 11.2-13.8 sec) INR: 1.07 APTT: 57 sec (RR: ... (Read 59 times)

panfilo

  • Hero Member
  • *****
  • Posts: 572
on: Jun 25, 2018
Interpret the following results:
 
  PT: 11.8 sec (RR: 11.2-13.8 sec)
  INR: 1.07
  APTT: 57 sec (RR: 23-32 sec)
  BT: 12 min
  Ristocetin aggregation: decreased aggregation
 
  Based on this information, from what is the patient most likely suffering?
  a. Hemophilia A
  b. Bernard-Soulier syndrome
  c. DIC
  d. von Willebrand's disease

Question 2

Explain the pathophysiology of the following and why each typically has normal coagulation screening tests.
 
  a. Bernard-Soulier syndrome
  b. Glanzmann's thrombasthenia
  c. -storage pool disease
  d. Gray platelet syndrome
 
  What will be an ideal response?


wshriver

  • Sr. Member
  • ****
  • Posts: 318
Reply #1 on: Jun 25, 2018
Answer to Question 1

Correct Answer: D

Answer to Question 2

Answer regarding pathophysiology: Bernard-Soulier syndrome: defect in glycoprotein Ib/IX
Glanzmann's thrombasthenia: defect in glycoprotein IIb/IIIa
-Storage pool disease: defect in dense granules
Gray platelet syndrome: defect in alpha granules
All four of these disorders are inherited qualitative platelet defects. All have defects in platelet function, not in the synthesis of coagulation factors and/or serine proteases. That is why the clot-based coagulation screening tests are typically normal. They all have prolonged bleeding time because the bleeding time assesses platelet function in vivo and have abnormal platelet aggregation studies.


Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
« previous next »
 

Did you know?

Although not all of the following muscle groups are commonly used, intramuscular injections may be given into the abdominals, biceps, calves, deltoids, gluteals, laterals, pectorals, quadriceps, trapezoids, and triceps.

Did you know?

About one in five American adults and teenagers have had a genital herpes infection—and most of them don't know it. People with genital herpes have at least twice the risk of becoming infected with HIV if exposed to it than those people who do not have genital herpes.

Did you know?

About 3% of all pregnant women will give birth to twins, which is an increase in rate of nearly 60% since the early 1980s.

Did you know?

The calories found in one piece of cherry cheesecake could light a 60-watt light bulb for 1.5 hours.

Did you know?

Serum cholesterol testing in adults is recommended every 1 to 5 years. People with diabetes and a family history of high cholesterol should be tested even more frequently.

Examples of the results of sexual selection, a type of natural selection. Examples of the results of sexual selection, a type of natural selection.
Graphic display of hypothetical results of a predator removal experiment. Graphic display of hypothetical results of a predator removal experiment.
Volvulus. A volvulus results when the small intestine twists, causing an obstruction that can lead t Volvulus. A volvulus results when the small intestine twists, causing an obstruction that can lead t
Monitoring and Following Up on Laboratory Test Results Monitoring and Following Up on Laboratory Test Results
Results of one round of replication of DNA Results of one round of replication of DNA
The results of reciprocal crosses between streptomycin-resistant and streptomycin-sensitive The results of reciprocal crosses between streptomycin-resistant and streptomycin-sensitive
Video: Introduction to Eating Disorders

For a complete list of videos, visit our video library