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Author Question: Compare and contrast systemic and physiologic fibrinolysis. What will be an ideal ... (Read 113 times)

fnuegbu

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on: Jun 25, 2018
Compare and contrast systemic and physiologic fibrinolysis.
 
  What will be an ideal response?

Question 2

What are the roles of thrombin in coagulation?
 
  What will be an ideal response?


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peilian

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Reply #1 on: Jun 25, 2018
Answer to Question 1

Answer: Physiologic fibrinolysis: highly fibrin-specific; occurs when PLN (plasmin) attaches to fibrin
Systemic fibrinolysis: brought on by PLG (plasminogen) activation, depletion of alpha2-antiplasmin, circulating plasmin and fibrinogen breakdown

Answer to Question 2

Answer:
 Platelet aggregation
 Factor activation (FV, VIII, XI)
 Anticoagulant activity (via PC, PS, and thrombomodulin)
 Fibrin formation (fibrinogen cleavage)
 Fibrin stabilization (FXIII activation)
Fibrinolysis (TAFI activation)
 Tissue repair


fnuegbu

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Reply 2 on: Jun 25, 2018
Great answer, keep it coming :)

amit

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Reply 3 on: Yesterday
Wow, this really help

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