This topic contains a solution. Click here to go to the answer
« previous next »

Author Question: Describe megakaryocyte development and the role of endomitosis and thrombopoietin in this process. ... (Read 47 times)

pragya sharda

  • Hero Member
  • *****
  • Posts: 566
on: Jun 25, 2018
Describe megakaryocyte development and the role of endomitosis and thrombopoietin in this process.
 
  What will be an ideal response?

Question 2

Which of the following best describes the role of platelet factor 4?
 
  a. Stimulates platelet aggregation
  b. Contributes to fibrin formation
  c. Neutralizes heparin
  d. Acts as a mitogenic factor


Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
Marked as best answer by a Subject Expert

medine

  • Sr. Member
  • ****
  • Posts: 344
Reply #1 on: Jun 25, 2018
Answer to Question 1

Answer: Platelets develop from megakaryocytes. Megakaryocyte maturation is produced through endomitosis, which is different from mitosis because telophase is missing. As a result, nuclear duplication occurs without nuclear or cytoplasmic division. The resulting maturing cells are larger than in the previous stage. MK1 is smaller than MK2, which is smaller than MK3, which is smaller than MK4. The stages are very large (can reach up to 150 mcM), and can be easily spotted under low power when examining bone marrow specimens. These platelets respond to changes in thrombopoietin. Thrombopoietin interacts with c-MPL receptor on the megakaryocytes to induce thrombopoiesis and speed up the maturation time of the megakaryocyte. Mature platelets bud off the megakaryocyte and enter the circulation.

Answer to Question 2

Correct Answer: C


pragya sharda

  • Member
  • Posts: 566
Reply 2 on: Jun 25, 2018
:D TYSM

ryhom

  • Member
  • Posts: 366
Reply 3 on: Yesterday
Great answer, keep it coming :)

« previous next »
 

Did you know?

Medication errors are three times higher among children and infants than with adults.

Did you know?

In the ancient and medieval periods, dysentery killed about ? of all babies before they reach 12 months of age. The disease was transferred through contaminated drinking water, because there was no way to adequately dispose of sewage, which contaminated the water.

Did you know?

It is difficult to obtain enough calcium without consuming milk or other dairy foods.

Did you know?

Fatal fungal infections may be able to resist newer antifungal drugs. Globally, fungal infections are often fatal due to the lack of access to multiple antifungals, which may be required to be utilized in combination. Single antifungals may not be enough to stop a fungal infection from causing the death of a patient.

Did you know?

The first oncogene was discovered in 1970 and was termed SRC (pronounced "SARK").

The process of placing a stent in a blood vessel. (A) A catheter is used to place a collapsed stent The process of placing a stent in a blood vessel. (A) A catheter is used to place a collapsed stent
Development of the Internal Sex Organs Development of the Internal Sex Organs
Development Issues Development Issues
Stages of development in vertebrates. Stages of development in vertebrates.
Development of a Frog Development of a Frog
Fetal Development Fetal Development
Video: Audiology

For a complete list of videos, visit our video library