Initiation of apoptosis occurs primarily with: a. Activation ...

[asmith134]

Initiation of apoptosis occurs primarily with:
 
  a. Activation of p53
  b. Cleavage of appropriate caspases at timely intervals
  c. Stimulus from an inflammatory response
  d. Activation of BCL-2

Question 2

List three ways in which the caspase pathway can be activated. Explain the role of each, and indicate which arm of the caspase pathway will be activated.
 
  What will be an ideal response?

[thall411]

Answer to Question 1

Correct answer: B

Answer to Question 2

Answer: The extrinsic pathway of apoptosis is triggered by extracellular death signals (TNF, Fas Ligand, and CD95). The intrinsic pathway of apoptosis is triggered by intracellular signals in response to stress, exposure to cytotoxic agents, and radiation.