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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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Increased intake of vitamin D has been shown to reduce fractures up to 25% in older people.
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In 1835 it was discovered that a disease of silkworms known as muscardine could be transferred from one silkworm to another, and was caused by a fungus.
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The Romans did not use numerals to indicate fractions but instead used words to indicate parts of a whole.
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The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.