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More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
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ACTH levels are normally highest in the early morning (between 6 and 8 A.M.) and lowest in the evening (between 6 and 11 P.M.). Therefore, a doctor who suspects abnormal levels looks for low ACTH in the morning and high ACTH in the evening.
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Patients who cannot swallow may receive nutrition via a parenteral route—usually, a catheter is inserted through the chest into a large vein going into the heart.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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On average, someone in the United States has a stroke about every 40 seconds. This is about 795,000 people per year.