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Intradermal injections are somewhat difficult to correctly administer because the skin layers are so thin that it is easy to accidentally punch through to the deeper subcutaneous layer.
In 1844, Charles Goodyear obtained the first patent for a rubber condom.
Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
On average, the stomach produces 2 L of hydrochloric acid per day.
About 3% of all pregnant women will give birth to twins, which is an increase in rate of nearly 60% since the early 1980s.