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Cyanide works by making the human body unable to use oxygen.
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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
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Individuals are never “cured” of addictions. Instead, they learn how to manage their disease to lead healthy, balanced lives.
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Everyone has one nostril that is larger than the other.