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In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.
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In the ancient and medieval periods, dysentery killed about ? of all babies before they reach 12 months of age. The disease was transferred through contaminated drinking water, because there was no way to adequately dispose of sewage, which contaminated the water.
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In 1844, Charles Goodyear obtained the first patent for a rubber condom.
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After a vasectomy, it takes about 12 ejaculations to clear out sperm that were already beyond the blocked area.