Order: Hycamtin (topotecan HCl) 1.5 mg/mIV daily for five days, ...

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Order: Hycamtin (topotecan HCl) 1.5 mg/mIV daily for five days, repeat every 21 days. The label on the vial reads 4 mg, and the manufacturer's directions state: Reconstitute each 4 mg with 4 mL of sterile water.
 
  Withdraw the dose and further dilute in 50 mL D5W and infuse over 30 minutes. Calculate the rate of flow in milliliters per hour for a patient who weighs 92 kg and is 183 cm tall. 1. 106 mL/h
  2. 114 mL/h
  3. 100 mL/h
  4. 87.5 mL/h

Question 2

Order: Verapamil HCl 0.075 mg/kg IV push over two min. The label on the vial reads 5 mg/2 mL, and the patient weighs 80 kg. How many mL/min. will you administer?
 
  1. 2.4 mL/min
  2. 1.2 mL/min
  3. 0.6 mL/min
  4. 3 mL/min

[quynhmickitran]

Answer to Question 1

1

Global Rationale: 2.16 m2  1.5 = 3.24 mg = 3.24 mL; 53 ml/0.5 h = 106 mL/h.

Answer to Question 2

2

Global Rationale: 0.075 mg/kg  80 kg = 6 mg to be administered. 2.4 mL/2 min = 1.2 mL/min.