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Human kidneys will clean about 1 million gallons of blood in an average lifetime.
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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
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In 2012, nearly 24 milliion Americans, aged 12 and older, had abused an illicit drug, according to the National Institute on Drug Abuse (NIDA).
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More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
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According to the FDA, adverse drug events harmed or killed approximately 1,200,000 people in the United States in the year 2015.