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Acetaminophen (Tylenol) in overdose can seriously damage the liver. It should never be taken by people who use alcohol heavily; it can result in severe liver damage and even a condition requiring a liver transplant.
Thyroid conditions may make getting pregnant impossible.
The B-complex vitamins and vitamin C are not stored in the body and must be replaced each day.
Though methadone is often used to treat dependency on other opioids, the drug itself can be abused. Crushing or snorting methadone can achieve the opiate "rush" desired by addicts. Improper use such as these can lead to a dangerous dependency on methadone. This drug now accounts for nearly one-third of opioid-related deaths.
More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.

