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In 1864, the first barbiturate (barbituric acid) was synthesized.
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The Romans did not use numerals to indicate fractions but instead used words to indicate parts of a whole.
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Blood in the urine can be a sign of a kidney stone, glomerulonephritis, or other kidney problems.
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Opium has influenced much of the world's most popular literature. The following authors were all opium users, of varying degrees: Lewis Carroll, Charles, Dickens, Arthur Conan Doyle, and Oscar Wilde.
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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.