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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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More than 34,000 trademarked medication names and more than 10,000 generic medication names are in use in the United States.
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A headache when you wake up in the morning is indicative of sinusitis. Other symptoms of sinusitis can include fever, weakness, tiredness, a cough that may be more severe at night, and a runny nose or nasal congestion.
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By definition, when a medication is administered intravenously, its bioavailability is 100%.
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The FDA recognizes 118 routes of administration.