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Sildenafil (Viagra®) has two actions that may be of consequence in patients with heart disease. It can lower the blood pressure, and it can interact with nitrates. It should never be used in patients who are taking nitrates.
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In 1886, William Bates reported on the discovery of a substance produced by the adrenal gland that turned out to be epinephrine (adrenaline). In 1904, this drug was first artificially synthesized by Friedrich Stolz.
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The horizontal fraction bar was introduced by the Arabs.
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The immune system needs 9.5 hours of sleep in total darkness to recharge completely.
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In 1864, the first barbiturate (barbituric acid) was synthesized.