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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
Cancer has been around as long as humankind, but only in the second half of the twentieth century did the number of cancer cases explode.
Sildenafil (Viagra®) has two actions that may be of consequence in patients with heart disease. It can lower the blood pressure, and it can interact with nitrates. It should never be used in patients who are taking nitrates.
As the western states of America were settled, pioneers often had to drink rancid water from ponds and other sources. This often resulted in chronic diarrhea, causing many cases of dehydration and death that could have been avoided if clean water had been available.