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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
There are approximately 3 million unintended pregnancies in the United States each year.
For pediatric patients, intravenous fluids are the most commonly cited products involved in medication errors that are reported to the USP.
More than 34,000 trademarked medication names and more than 10,000 generic medication names are in use in the United States.
Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.