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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.
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Oliver Wendell Holmes is credited with introducing the words "anesthesia" and "anesthetic" into the English language in 1846.
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There are 60,000 miles of blood vessels in every adult human.
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The FDA recognizes 118 routes of administration.
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More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.