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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
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Multiple sclerosis is a condition wherein the body's nervous system is weakened by an autoimmune reaction that attacks the myelin sheaths of neurons.
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Addicts to opiates often avoid treatment because they are afraid of withdrawal. Though unpleasant, with proper management, withdrawal is rarely fatal and passes relatively quickly.
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Alcohol acts as a diuretic. Eight ounces of water is needed to metabolize just 1 ounce of alcohol.
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Cucumber slices relieve headaches by tightening blood vessels, reducing blood flow to the area, and relieving pressure.

