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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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Approximately 15–25% of recognized pregnancies end in miscarriage. However, many miscarriages often occur before a woman even knows she is pregnant.
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The immune system needs 9.5 hours of sleep in total darkness to recharge completely.
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About 100 new prescription or over-the-counter drugs come into the U.S. market every year.
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More than 150,000 Americans killed by cardiovascular disease are younger than the age of 65 years.