A patient at high risk of developing VAP has acquired late-onset ...

[mynx]

A patient at high risk of developing VAP has acquired late-onset VAP. Which of the following combinations of antibiotics is suitable for this patient to receive as initial combination therapy? I. methicillin-sensitive Staphylococcus aureus II. antipseudomonal fluoroquinolone plus vancomycin III. antipseudomonal, cephalosporin, beta-lactam/beta-lactamase inhibitor IV. carbapenems plus aminoglycoside
 
  A. I, IV only
  B. II, III only
  C. II, III, IV only
  D. I, II, III, IV

Question 2

Which of the following antibiotics are bactericidal in time-dependent fashion? I. aminoglycosides II. fluoroquinolones III. vancomycin IV. beta-lactams
 
  A. I, II only
  B. II, III only
  C. III, IV only
  D. I, II, IV only

[wilsonbho]

Answer to Question 1

ANS: C
A. Incorrect response: See explanation C.
B. Incorrect response: See explanation C.
C. Correct response: Using antibiotics from different classes will increase the chance of covering pathogens resistant to the class of antimicrobial the patient received. An antipseudomonal, cephalosporin, beta-lactam/beta-lactamase inhibitor, or carbapenems plus an aminoglycoside, or antipseudomonal fluoroquinolone plus anti-MRSA antibiotic (linezolid or vancomycin) is the recommended initial combination for late-onset and for VAP in high-risk patients.
D. Incorrect response: See explanation C

Answer to Question 2

ANS: C
A. Incorrect response: See explanation C.
B. Incorrect response: See explanation C.
C. Correct response: Aminoglycosides and fluoroquinolones are bactericidal in a concentration-dependent fashion with postdose effect. Beta-lactams and vancomycin are bactericidal in time-dependent manner with no postantibiotic effect.
D. Incorrect response: See explanation C.

[mynx]

Correct answers!

[wilsonbho]

Great! Please up vote