When administering aerosolized pentamidine, what should the ...

[DyllonKazuo]

When administering aerosolized pentamidine, what should the respiratory care practitioner do?
 
  1. Use a nebulizer that produces particles in the 1- to 2-m mean mass aerodynamic diameter (MMAD) range.
  2. Use a nebulizer system with one-way valves and scavenging expiratory filters.
  3. Provide isolation and an environmental containment system.
  4. Screen patients for human immunodeficiency virus (HIV).
  a. 1 and 2 only
  b. 2 and 4 only
  c. 1, 2, and 3 only
  d. 1, 2, 3, and 4

Question 2

Zileuton belongs to which of the following categories?
 
  a. Cromolyn-like agents
  b. Leukotriene modifiers
  c. Anti-IgE agents
  d. Anti-IgA agents

[aloop]

Answer to Question 1

ANS: C
When administering aerosolized pentamidine, isolation, an environmental containment system (e.g., a booth or negative pressure room), and personnel barrier protection should be provided. Subjects should be screened for tuberculosis. The drug is given using a nebulizer system with one-way valves and scavenging expiratory filters (e.g., the Respirgard). This reduces environ-mental contamination. Nebulizer systems capable of producing an MMAD of 1 to 2 m for pe-ripheral lung deposition may reduce coughing.

Answer to Question 2

ANS: B
Zileuton inhibits the 5-lipoxygenase enzyme that catalyzes the formation of leukotrienes from arachidonic acid, as also shown in Figure 35-8.

[DyllonKazuo]

TYSM

[kilada]

Gracias!